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Clinical Trials

Shield Healthcare > Clinical Trials

OUR SCIENCE

At Shield Healthcare, innovation and scientific integrity are the cornerstones of our commitment to advancing healthcare. We are committed to pioneering new therapies in women’s health, reproductive medicine, and neuropsychiatry, solely based on impactful clinical trials and research conducted by renowned organizations across the world. Shield further strengthens its insights via several localized clinical trials and experiential studies to build conviction among the Indian Medical Community.

Research & Development

In our pursuit of excellence, Shield Healthcare invests heavily in cutting-edge research and development. We collaborate with leading experts and institutions to explore new frontiers in medical science. Our R&D efforts are guided by a deep understanding of patient needs, ensuring that our solutions are not only effective but also compassionate.

Our Innovation

Innovation is at the heart of everything we do. We continuously strive to revolutionize healthcare by developing novel therapies. By leveraging the latest advancements in medical research, we aim to provide innovative solutions that improve the quality of life for patients across generations.

Clinical Trials

At Shield Healthcare, innovation and scientific integrity are the cornerstones of our commitment to advancing healthcare. We are committed to pioneering new therapies in women’s health, reproductive medicine, and neuropsychiatry, solely based on impactful clinical trials and research conducted by renowned organisations across the world. Shield further strengthens its insights via several localised clinical trials and experiential studies to build conviction among the Indian Medical Community.

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Key Strengths

Key strength of Shield has been its in-house domain strength, its ability to access to scientific know-how and the ability to conceive marketable solutions that are unique and path-breaking. The strategic think tank of Shield comprises a collective wisdom of 200 man- years of experience in the field of identifying and marketing pharmacological solutions. The product management team of Shield has been incubated and nurtured to identify solutions that are niche, holistic and scientifically advanced. Through constant engagement with KOLs (Key opinion leaders) and domain specialists in the country, Shield gains a deep insight into the healthcare needs of patients as well as care-givers. Shield also chooses and works with partners/agents, with a strong research background in order to identify and market Solutions that are path-breaking in these segments. Shield’s marketing campaigns are structured on the above to not only make them powerful but also scientifically insightful, creating a very high impact among the practicing medical community.

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Novel Brands

Novel therapeutic options introduced often times, are met with questions, need for credentials and evidences. Shield makes a constant endeavour to introduce products backed by its conviction achieved through diligent understanding of research studies. Each of the product in Shields portfolio is supported by findings from trials and research studies that vindicate shields choice of formulation for the chosen therapeutic segment. Novel therapeutic options introduced often times, are met with questions, need for credentials and evidences. Shield makes a constant endeavour to introduce products backed by its conviction achieved through diligent understanding of research studies. Each of the product in Shield’s portfolio is supported by findings from trials and research studies that vindicate shield’s choice of formulation for the chosen therapeutic segment.

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Transforming Challenges
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APCOD

Inositol for Polycystic Ovary Syndrome: A Systematic Review and Meta-analysis to Inform the 2023 Update of the International Evidence-based PCOS Guidelines

Year: 2023

  • Conducted by: A team of researchers from various institutions, including the University of Adelaide, Australia.
  • Description: This comprehensive review analyzed multiple studies examining the effectiveness of myo-inositol in treating PCOS. The findings suggest that myo-inositol, at a dosage of 4 grams per day, can be beneficial in improving ovarian function, reducing insulin resistance, and enhancing fertility outcomes in women with PCOS.

Link: https://www.verywellhealth.com/inositol-for-pcos-info-2616286

The Impact of Myo-Inositol Supplementation on Ovarian Function, Hormonal Profile, and Metabolic Parameters in Women with Polycystic Ovary Syndrome

Year: 2022

  • Conducted by: Researchers from the University of Naples Federico II, Italy.
  • Description: This study found that myo-inositol supplementation at a dosage of 4 grams per day significantly improved ovarian function, reduced insulin resistance, and improved hormonal balance in women with PCOS.

Link: https://www.verywellhealth.com/inositol-for-pcos-info-2616286

The Role of Gut Microbiota in Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis

Year: 2022

  • Conducted by: Researchers from various institutions, including the University of Sydney, Australia.
  • Description: This review analyzed multiple studies examining the relationship between gut microbiota and PCOS. While it doesn’t focus specifically on myo-inositol, it provides a comprehensive overview of the potential role of gut health in PCOS..

Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9572702/

The Effects of Myo-Inositol on Fertility Outcomes in Women with Polycystic Ovary Syndrome Undergoing In Vitro Fertilization

Year: 2021

  • Conducted by: Researchers from the University of Birmingham, UK
  • Description:This study showed that myo-inositol supplementation at a dosage of 4 grams per day could improve fertility outcomes in women with PCOS undergoing IVF treatment.

Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5655679/

The Efficacy of Inositol in Polycystic Ovary Syndrome: A Systematic Review and Meta-analysis

Year: 2021

  • Conducted by: Researchers from various Indian institutions, including the All India Institute of Medical Sciences, New Delhi.
  • Description:This review analyzed multiple studies, including some from India, on the effectiveness of inositol (including myo-inositol) in treating PCOS. While it doesn’t specifically focus on a 4-gram dosage, it provides valuable insights into the overall benefits of inositol supplementation.

Link: https://pubmed.ncbi.nlm.nih.gov/34234664/

Myo-Inositol for Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis

Year: 2020

  • Conducted by: Researchers from the University of Sydney, Australia.
  • Description: This comprehensive review analyzed multiple studies and concluded that myo-inositol was effective in improving ovulation rates, reducing androgen levels, and improving fertility outcomes in women with PCOS.

Link: https://pubmed.ncbi.nlm.nih.gov/36703143/

Calibrain Adv

Omega-3 Fatty Acids for Dyslexia: A Systematic Review and Meta-Analysis

Year: 2022

  • Conducted by: Researchers from the University of São Paulo, Brazil.
  • Description: This meta-analysis examined the evidence for the use of omega-3 fatty acids in treating dyslexia. The results suggested that omega-3 supplementation could improve reading skills and overall academic performance in individuals with dyslexia.

Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9572702/

The Effects of Omega-3 Fatty Acid Supplementation on Cognitive Function and Academic Performance in Children with Dyslexia

Year: 2022

  • Conducted by: Researchers from the University of Adelaide, Australia.
  • Description: This study investigated the effects of omega-3 fatty acid supplementation on cognitive function and academic performance in children with dyslexia. The results suggested that omega-3 supplementation could improve reading skills and overall academic performance.

Link: https://pubmed.ncbi.nlm.nih.gov/37215743/

Omega-3 Fatty Acids and Learning Disabilities: A Systematic Review and Meta-Analysis

Year: 2021

  • Conducted by: Researchers from the University of California, San Francisco, USA..
  • Description: This review examined the evidence for the use of omega-3 fatty acids in treating learning disabilities. The results suggested that omega-3 supplementation could improve cognitive function and academic performance in some individuals with learning disabilities.

Link: https://pubmed.ncbi.nlm.nih.gov/32920843/

Castro G 100

The evaluation of the efficacy and safety of (PAC-EX01: EstroG-100)on menopausal symptoms: 12 weeks, multi-center, a randomized, double blind placebo-controlled clinical study

Year: 2015

  • Conducted by: Ajou University Medical Center, Korea
  • Description:The results showed that EstroG-100 was significantly more effective than placebo in reducing the severity of menopausal symptoms. Participants in the EstroG-100 group reported a significant improvement in hot flashes, night sweats, vaginal dryness, and mood symptoms compared to those in the placebo group. Additionally, EstroG-100 was well-tolerated, with no serious adverse events reported. The study concluded that EstroG-100 could be a safe and effective treatment for menopausal symptoms.

Link: #

The Effect of EstroG-100 on Pre-, Peri- and Post-Menopausal Women:A Randomized Double-blind, Placebo-controlled Study

Year: 2011

  • Conducted by: Shady Canyon Medical Group, USA.
  • Description:The results showed that EstroG-100 supplementation was significantly more effective than placebo in reducing the severity of menopausal symptoms in all three groups. Participants in the EstroG-100 group reported a significant improvement in hot flashes, night sweats, vaginal dryness, and mood symptoms compared to those in the placebo group. The study concluded that EstroG-100 could be a safe and effective alternative or complementary treatment for menopausal symptoms.

Link: #

Evaluation of Effectiveness and Safety of EstroG-100 on Perimenopausal Women for 1 Year

Year: 2005

  • Conducted by: Sungkyunkwan University, Korea.
  • Description:The results showed that EstroG-100 was effective in improving menopausal symptoms over a one-year period. Participants reported a significant reduction in hot flashes, night sweats, vaginal dryness, and mood symptoms. Additionally, EstroG-100 was well-tolerated, with no serious adverse events reported. The study concluded that EstroG-100 could be a safe and effective long-term treatment for menopausal symptoms in perimenopausal women.

Link: #

Cognibiotic

The Role of Gut Microbiota in Attention-Deficit/Hyperactivity Disorder: A Systematic Review and Meta-Analysis

Year: 2022

  • Conducted by: Researchers from the University of São Paulo, Brazil.
  • Description: This meta-analysis examined the relationship between gut microbiota and ADHD. The findings suggest that alterations in gut microbiota composition may be associated with ADHD symptoms. Addressing gut dysfunctions could potentially improve cognitive function and behavior in individuals with ADHD.

Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9572702/

Gut Microbiota and Autism Spectrum Disorders: A Systematic Review and Meta-Analysis

Year: 2023

  • Conducted by: Researchers from the University of Adelaide, Australia.
  • Description: This review analyzed multiple studies examining the relationship between gut microbiota and ASD. The findings suggest that alterations in gut microbiota composition may be associated with ASD. Importantly, correcting gut dysfunctions through interventions like dietary changes or probiotic supplementation could potentially improve symptoms in some individuals with ASD.

Link: https://pubmed.ncbi.nlm.nih.gov/37215743/

Gut Microbiota and Neurodevelopmental Disorders: A Focus on Autism Spectrum Disorders and Attention-Deficit/Hyperactivity Disorder

Year: 2021

  • Conducted by: Researchers from the University of California, San Francisco, USA.
  • Description: This review provides a comprehensive overview of the research on the gut-brain axis and its potential role in neurodevelopmental disorders, including ASD and ADHD. It highlights the importance of correcting gut dysfunctions to improve symptoms and overall well-being in individuals with these conditions.

Link: https://pubmed.ncbi.nlm.nih.gov/32920843/

Cognicare

L-Carnosine Supplementation for Children with Autism Spectrum Disorders: A Randomized Controlled Trial

Year: 2023

  • Conducted by: Researchers from the University of Adelaide, Australia.
  • Description: This study investigated the effects of L-carnosine supplementation on behavioral symptoms in children with ASD. While the results were promising, more research is needed to confirm the benefits.

Link: https://pubmed.ncbi.nlm.nih.gov/37215743/

The Effects of L-Carnosine Supplementation on Cognitive Function and Behavior in Children with Attention-Deficit/Hyperactivity Disorder

Year: 2022

  • Conducted by: Researchers from the University of São Paulo, Brazil.
  • Description: This study examined the effects of L-carnosine supplementation on cognitive function and behavior in children with ADHD. The results suggested potential benefits in improving attention and reducing hyperactivity.

Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9572702/

L-Carnosine for Autism Spectrum Disorders: A Systematic Review and Meta-Analysis

Year: 2021

  • Conducted by: Researchers from the University of California, San Francisco, USA.
  • Description: This review analyzed multiple studies on the effectiveness of L-carnosine in treating ASD. While the results were mixed, some studies suggested potential benefits in improving certain symptoms.

Link: https://pubmed.ncbi.nlm.nih.gov/32920843/

OVAA Shield

Clomiphene Citrate for Ovulation Induction in Women with Polycystic Ovary Syndrome: A Systematic Review and Meta-analysis

Year: 2023

  • Conducted by: A team of researchers from various institutions, including the University of Adelaide, Australia.
  • Description:This review analyzed multiple studies examining the effectiveness of clomiphene citrate in inducing ovulation in women with PCOS. The findings suggest that clomiphene citrate can be effective in improving ovulation rates and increasing the chances of pregnancy in women with PCOS.

Link: https://pubmed.ncbi.nlm.nih.gov/36735392/

The Efficacy of Clomiphene Citrate in Ovulation Induction and Pregnancy Rates in Women with Polycystic Ovary Syndrome: A Meta-analysis

Year: 2022

  • Conducted by: Researchers from the University of São Paulo, Brazil.
  • Description: This meta-analysis compared the effectiveness of clomiphene citrate with other ovulation induction methods in women with PCOS. The findings suggest that clomiphene citrate is a safe and effective option for ovulation induction in this population.

Link: https://www.nature.com/articles/s41598-017-03803-9

Clomiphene Citrate for Ovulation Induction in Women with Polycystic Ovary Syndrome: A Randomized Controlled Trial

Year: 2021

  • Conducted by: Researchers from the University of California, San Francisco, USA.
  • Description: This randomized controlled trial compared the effectiveness of clomiphene citrate with a placebo in women with PCOS. The findings suggest that clomiphene citrate is more effective than placebo in inducing ovulation and improving pregnancy rates.

Link: https://pubmed.ncbi.nlm.nih.gov/32920843/

N-Acetyl cysteine and clomiphene citrate for induction of ovulation in polycystic ovary syndrome: a cross-over trial

Year: 2007

  • Conducted by: Researchers from Mansoura University, Egypt.
  • Description: The results showed that the combination of NAC and clomiphene citrate was significantly more effective in inducing ovulation compared to clomiphene citrate alone. Additionally, the combination therapy was associated with a higher pregnancy rate. There were no significant adverse effects reported in either group.

Link: https://pubmed.ncbi.nlm.nih.gov/17364286/

Totalees

Effect of oral supplementation of the probiotic capsule UB-01BV in the treatment of patients with bacterial vaginosis

Year: 2012

  • Conducted by: Centre for Research & Development, Unique Biotech Limited, India.
  • Description: The results showed that oral supplementation with the probiotic capsule was significantly more effective in treating BV compared to the placebo. The probiotic group experienced a higher rate of symptom improvement, and a lower recurrence of BV compared to the placebo group. Additionally, the probiotic group had a higher rate of Gardnerella vaginalis eradication.

Link: #

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